Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway

Our previous study manifested that lanthanum chloride (LaCl(3)) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl(3). Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected....

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Detalles Bibliográficos
Autores principales: Fang, Shanyu, Zhang, Ping, Chen, Xinping, Liu, Fujun, Wang, Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714849/
https://www.ncbi.nlm.nih.gov/pubmed/34977076
http://dx.doi.org/10.3389/fmed.2021.776876
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author Fang, Shanyu
Zhang, Ping
Chen, Xinping
Liu, Fujun
Wang, Fen
author_facet Fang, Shanyu
Zhang, Ping
Chen, Xinping
Liu, Fujun
Wang, Fen
author_sort Fang, Shanyu
collection PubMed
description Our previous study manifested that lanthanum chloride (LaCl(3)) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl(3). Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected. LaCl(3) induced more cell death and apoptosis caused by DDP in two cell lines, accompanied by upregulation of Bax and Cleaved caspase 3 proteins, and downregulation of Bcl-2 protein. LaCl(3) also could decrease RAD51 protein by inactivation of the PI3K/Akt pathway. These data indicated that LaCl(3) could be a potential drug to modulate DDP resistance by inactivating of PI3K/Akt pathway and attenuating DNA repair in ovarian cancer.
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spelling pubmed-87148492021-12-30 Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway Fang, Shanyu Zhang, Ping Chen, Xinping Liu, Fujun Wang, Fen Front Med (Lausanne) Medicine Our previous study manifested that lanthanum chloride (LaCl(3)) can enhance the anticancer ability of cisplatin (DDP) in ovarian cancer cells. Here, ovarian cancer cells SKOV3 and SKOV3/DDP were subjected to DDP and LaCl(3). Cell viability, apoptosis, DNA repair, and PI3K/Akt pathway were detected. LaCl(3) induced more cell death and apoptosis caused by DDP in two cell lines, accompanied by upregulation of Bax and Cleaved caspase 3 proteins, and downregulation of Bcl-2 protein. LaCl(3) also could decrease RAD51 protein by inactivation of the PI3K/Akt pathway. These data indicated that LaCl(3) could be a potential drug to modulate DDP resistance by inactivating of PI3K/Akt pathway and attenuating DNA repair in ovarian cancer. Frontiers Media S.A. 2021-12-15 /pmc/articles/PMC8714849/ /pubmed/34977076 http://dx.doi.org/10.3389/fmed.2021.776876 Text en Copyright © 2021 Fang, Zhang, Chen, Liu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Fang, Shanyu
Zhang, Ping
Chen, Xinping
Liu, Fujun
Wang, Fen
Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway
title Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway
title_full Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway
title_fullStr Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway
title_full_unstemmed Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway
title_short Lanthanum Chloride Sensitizes Cisplatin Resistance of Ovarian Cancer Cells via PI3K/Akt Pathway
title_sort lanthanum chloride sensitizes cisplatin resistance of ovarian cancer cells via pi3k/akt pathway
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714849/
https://www.ncbi.nlm.nih.gov/pubmed/34977076
http://dx.doi.org/10.3389/fmed.2021.776876
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