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Soluble antigens derived from Coxiella burnetii elicit protective immunity in three animal models without inducing hypersensitivity

Q fever is caused by the intracellular bacterium Coxiella burnetii, for which there is no approved vaccine in the United States. A formalin-inactivated whole-cell vaccine (WCV) from virulent C. burnetii NMI provides single-dose long-lived protection, but concerns remain over vaccine reactogenicity....

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Detalles Bibliográficos
Autores principales: Gregory, Anthony E., van Schaik, Erin J., Fratzke, Alycia P., Russell-Lodrigue, Kasi E., Farris, Christina M., Samuel, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714860/
https://www.ncbi.nlm.nih.gov/pubmed/35028605
http://dx.doi.org/10.1016/j.xcrm.2021.100461