The Disassociation of the A20/HSP90 Complex via Downregulation of HSP90 Restores the Effect of A20 Enhancing the Sensitivity of Hepatocellular Carcinoma Cells to Molecular Targeted Agents

NF-κB (nuclear factor κB) is a regulator of hepatocellular cancer (HCC)-related inflammation and enhances HCC cells’ resistance to antitumor therapies by promoting cell survival and anti-apoptosis processes. In the present work, we demonstrate that A20, a dominant-negative regulator of NF-κB, forms...

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Detalles Bibliográficos
Autores principales: Shen, Li-jun, Sun, Hui-wei, Chai, Yan-yao, Jiang, Qi-yu, Zhang, Jian, Li, Wen-ming, Xin, Shao-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714928/
https://www.ncbi.nlm.nih.gov/pubmed/34976842
http://dx.doi.org/10.3389/fonc.2021.804412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8714928/
https://www.ncbi.nlm.nih.gov/pubmed/34976842
http://dx.doi.org/10.3389/fonc.2021.804412

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