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Human lung cDC1 drive increased perforin-mediated NK cytotoxicity in chronic obstructive pulmonary disease

In chronic obstructive pulmonary disease (COPD), lung natural killer cells (NKs) lyse autologous lung epithelial cells in vitro, but underlying mechanisms and their relationship to epithelial cell apoptosis in vivo are undefined. Although this cytolytic capacity of lung NKs depends on priming by den...

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Detalles Bibliográficos
Autores principales:	Pallazola, Alexander M., Rao, Jessica X., Mengistu, Dawit T., Morcos, Maria S., Toma, Mariam S., Stolberg, Valerie R., Tretyakova, Alexandra, McCloskey, Lisa, Curtis, Jeffrey L., Freeman, Christine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715029/ https://www.ncbi.nlm.nih.gov/pubmed/34704847 http://dx.doi.org/10.1152/ajplung.00322.2020

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