Conformational dynamics during misincorporation and mismatch extension defined using a DNA polymerase with a fluorescent artificial amino acid

High-fidelity DNA polymerases select the correct nucleotide over the structurally similar incorrect nucleotides with extremely high specificity while maintaining fast rates of incorporation. Previous analysis revealed the conformational dynamics and complete kinetic pathway governing correct nucleot...

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Detalles Bibliográficos
Autores principales: Dangerfield, Tyler L., Kirmizialtin, Serdal, Johnson, Kenneth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715121/
https://www.ncbi.nlm.nih.gov/pubmed/34838820
http://dx.doi.org/10.1016/j.jbc.2021.101451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715121/
https://www.ncbi.nlm.nih.gov/pubmed/34838820
http://dx.doi.org/10.1016/j.jbc.2021.101451

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