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Slowest-first protein translation scheme: Structural asymmetry and co-translational folding
Proteins are translated from the N to the C terminus, raising the basic question of how this innate directionality affects their evolution. To explore this question, we analyze 16,200 structures from the Protein Data Bank (PDB). We find remarkable enrichment of α helices at the C terminus and β stra...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715247/ https://www.ncbi.nlm.nih.gov/pubmed/34813729 http://dx.doi.org/10.1016/j.bpj.2021.11.024 |