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Cannabinoid control of gingival immune activation in chronically SIV-infected rhesus macaques involves modulation of the indoleamine-2,3-dioxygenase-1 pathway and salivary microbiome

BACKGROUND: HIV/SIV-associated periodontal disease (gingivitis/periodontitis) (PD) represents a major comorbidity affecting people living with HIV (PLWH) on combination anti-retroviral therapy (cART). PD is characterized by chronic inflammation and dysbiosis. Nevertheless, the molecular mechanisms a...

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Detalles Bibliográficos
Autores principales: McDew-White, Marina, Lee, Eunhee, Alvarez, Xavier, Sestak, Karol, Ling, Binhua J, Byrareddy, Siddappa N, Okeoma, Chioma M, Mohan, Mahesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715300/
https://www.ncbi.nlm.nih.gov/pubmed/34954656
http://dx.doi.org/10.1016/j.ebiom.2021.103769