Allosteric Effect of Nanobody Binding on Ligand-Specific Active States of the β2 Adrenergic Receptor

[Image: see text] Nanobody binding stabilizes G-protein-coupled receptors (GPCR) in a fully active state and modulates their affinity for bound ligands. However, the atomic-level basis for this allosteric regulation remains elusive. Here, we investigate the conformational changes induced by the bind...

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Detalles Bibliográficos
Autores principales: Chen, Yue, Fleetwood, Oliver, Pérez-Conesa, Sergio, Delemotte, Lucie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715506/
https://www.ncbi.nlm.nih.gov/pubmed/34780174
http://dx.doi.org/10.1021/acs.jcim.1c00826

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715506/
https://www.ncbi.nlm.nih.gov/pubmed/34780174
http://dx.doi.org/10.1021/acs.jcim.1c00826

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