Computational Study Reveals the Role of Water Molecules in the Inhibition Mechanism of LAT1 by 1,2,3-Dithiazoles

[Image: see text] The L-type amino acid transporter LAT1, involved in many biological processes including the overexpression of some tumors, is considered a potential pharmacological target. The 1,2,3-Dithiazole scaffold was predicted to inhibit LAT1 by the formation of an intermolecular disulfide b...

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Detalles Bibliográficos
Autores principales: Prejanò, Mario, Romeo, Isabella, La Serra, Maria Antonietta, Russo, Nino, Marino, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715508/
https://www.ncbi.nlm.nih.gov/pubmed/34788052
http://dx.doi.org/10.1021/acs.jcim.1c01012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715508/
https://www.ncbi.nlm.nih.gov/pubmed/34788052
http://dx.doi.org/10.1021/acs.jcim.1c01012

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