Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites

[Image: see text] For using targeted covalent inhibitors (TCIs) as anticancer and antiviral drugs, we establish that the model compounds PCMPS (p-chloromercuriphenyl sulfate) and PCMB (p-chloromercuribenzoate) are inhibitors of the DEDDh family of exonucleases. The underlying mechanism is analyzed b...

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Detalles Bibliográficos
Autores principales: Huang, Kuan-Wei, Chen, Jing-Wen, Hua, Tzu-Yu, Chu, Yu-Yu, Chiu, Tsai-Yuan, Liu, Jung-Yu, Tu, Chun-I, Hsu, Kai-Cheng, Kao, Ya-Ting, Chu, Jhih-Wei, Hsiao, Yu-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715546/
https://www.ncbi.nlm.nih.gov/pubmed/34977900
http://dx.doi.org/10.1021/jacsau.1c00420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715546/
https://www.ncbi.nlm.nih.gov/pubmed/34977900
http://dx.doi.org/10.1021/jacsau.1c00420

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