Cargando…
Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites
[Image: see text] For using targeted covalent inhibitors (TCIs) as anticancer and antiviral drugs, we establish that the model compounds PCMPS (p-chloromercuriphenyl sulfate) and PCMB (p-chloromercuribenzoate) are inhibitors of the DEDDh family of exonucleases. The underlying mechanism is analyzed b...
Autores principales: | Huang, Kuan-Wei, Chen, Jing-Wen, Hua, Tzu-Yu, Chu, Yu-Yu, Chiu, Tsai-Yuan, Liu, Jung-Yu, Tu, Chun-I, Hsu, Kai-Cheng, Kao, Ya-Ting, Chu, Jhih-Wei, Hsiao, Yu-Yuan |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715546/ https://www.ncbi.nlm.nih.gov/pubmed/34977900 http://dx.doi.org/10.1021/jacsau.1c00420 |
Ejemplares similares
-
Lassa virus NP DEDDh 3’-5’ exoribonuclease activity is required for optimal viral RNA replication
por: Huang, Cheng, et al.
Publicado: (2023) -
Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease
por: Hastie, Kathryn M., et al.
Publicado: (2012) -
Understanding APE1 cellular functions by the structural preference of exonuclease activities
por: Liu, Tung-Chang, et al.
Publicado: (2021) -
Structure and function of TatD exonuclease in DNA repair
por: Chen, Yi-Chen, et al.
Publicado: (2014) -
How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T–product complexes
por: Hsiao, Yu-Yuan, et al.
Publicado: (2012)