Cargando…

Targeted Covalent Inhibitors Allosterically Deactivate the DEDDh Lassa Fever Virus NP Exonuclease from Alternative Distal Sites

[Image: see text] For using targeted covalent inhibitors (TCIs) as anticancer and antiviral drugs, we establish that the model compounds PCMPS (p-chloromercuriphenyl sulfate) and PCMB (p-chloromercuribenzoate) are inhibitors of the DEDDh family of exonucleases. The underlying mechanism is analyzed b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Kuan-Wei, Chen, Jing-Wen, Hua, Tzu-Yu, Chu, Yu-Yu, Chiu, Tsai-Yuan, Liu, Jung-Yu, Tu, Chun-I, Hsu, Kai-Cheng, Kao, Ya-Ting, Chu, Jhih-Wei, Hsiao, Yu-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715546/ https://www.ncbi.nlm.nih.gov/pubmed/34977900 http://dx.doi.org/10.1021/jacsau.1c00420

Ejemplares similares

Lassa virus NP DEDDh 3’-5’ exoribonuclease activity is required for optimal viral RNA replication
por: Huang, Cheng, et al.
Publicado: (2023)

Structural Basis for the dsRNA Specificity of the Lassa Virus NP Exonuclease
por: Hastie, Kathryn M., et al.
Publicado: (2012)

Understanding APE1 cellular functions by the structural preference of exonuclease activities
por: Liu, Tung-Chang, et al.
Publicado: (2021)

Structure and function of TatD exonuclease in DNA repair
por: Chen, Yi-Chen, et al.
Publicado: (2014)

How an exonuclease decides where to stop in trimming of nucleic acids: crystal structures of RNase T–product complexes
por: Hsiao, Yu-Yuan, et al.
Publicado: (2012)

Structural Insights Into DNA Repair by RNase T—An Exonuclease Processing 3′ End of Structured DNA in Repair Pathways
por: Hsiao, Yu-Yuan, et al.
Publicado: (2014)

Structural basis for overhang excision and terminal unwinding of DNA duplexes by TREX1
por: Huang, Kuan-Wei, et al.
Publicado: (2018)

MUT-7 Provides Molecular Insight into the Werner Syndrome Exonuclease
por: Hsu, Tsung-Yuan, et al.
Publicado: (2021)

Allosteric Effects of Permeating Cations on Gating Currents during K(+) Channel Deactivation
por: Chen, Fred S.P., et al.
Publicado: (1997)

Promotion of Bamboo Mosaic Virus Accumulation in Nicotiana benthamiana by 5′→3′ Exonuclease NbXRN4
por: Lee, Cheng-Cheng, et al.
Publicado: (2016)

Allosteric ring assembly and chemo-mechanical melting by the interaction between 5′-phosphate and λ exonuclease
por: Yoo, Jungmin, et al.
Publicado: (2015)

Non-covalent allosteric regulation of capsule catalysis
por: Martí-Centelles, Vicente, et al.
Publicado: (2020)

An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules
por: Yao, Yuan, et al.
Publicado: (2007)

LASSA: Emotion Detection via Information Fusion
por: Yu, Ning, et al.
Publicado: (2012)

Deciphering the Allosteric Effect of Antagonist Vismodegib on Smoothened Receptor Deactivation Using Metadynamics Simulation
por: An, Xiaoli, et al.
Publicado: (2019)

Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids
por: Huang, Kuan-Wei, et al.
Publicado: (2023)

Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐Selectivity
por: Quambusch, Lena, et al.
Publicado: (2019)

Systematic Analysis of Covalent and Allosteric Protein Kinase Inhibitors
por: Xerxa, Elena, et al.
Publicado: (2023)

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme
por: Lv, Zongyang, et al.
Publicado: (2018)

Highly sensitive protein detection via covalently linked aptamer to MoS(2) and exonuclease-assisted amplification strategy
por: Gao, Li, et al.
Publicado: (2017)

Aryloxyalkanoic Acids as Non-Covalent Modifiers of the Allosteric Properties of Hemoglobin
por: Omar, Abdelsattar M., et al.
Publicado: (2016)

Reduced Motor Cortex Deactivation in Individuals Who Suffer from Writer's Cramp
por: Tseng, Yi-Jhan, et al.
Publicado: (2014)

Mathematical model of distal radius orientation
por: Chen, Cheng-Kuang, et al.
Publicado: (2022)

Amplified Single Base-Pair Mismatch Detection via Aggregation of Exonuclease-Sheared Gold Nanoparticles
por: Wu, Shuo, et al.
Publicado: (2014)

APE1 distinguishes DNA substrates in exonucleolytic cleavage by induced space-filling
por: Liu, Tung-Chang, et al.
Publicado: (2021)

Is anaerobic digestion a reliable barrier for deactivation of pathogens in biosludge?
por: Zhao, Qian, et al.
Publicado: (2019)

Selective glycoprotein detection through covalent templating and allosteric click-imprinting
por: Stephenson-Brown, Alexander, et al.
Publicado: (2015)

Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt
por: Uhlenbrock, Niklas, et al.
Publicado: (2019)

A sequence-dependent exonuclease activity from Tetrahymena thermophila
por: Tom, Hui-I Kao, et al.
Publicado: (2010)

Spread of activation and deactivation in the brain: does age matter?
por: Gordon, Brian A., et al.
Publicado: (2014)

Reversible Deactivation Radical Polymerization Mediated by Nitroxides and Green Chemistry
por: Zaremski, M. Yu., et al.
Publicado: (2021)

Association between three exonuclease 1 polymorphisms and cancer risks: a meta-analysis
por: Chen, Zi-Yu, et al.
Publicado: (2016)

Construction and Immunological Evaluation of an Adenoviral Vector-Based Vaccine Candidate for Lassa Fever
por: Wang, Meirong, et al.
Publicado: (2021)

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases
por: Andersen, Jacob Lauwring, et al.
Publicado: (2018)

Covalent Allosteric Inhibitors of Akt Generated Using a Click Fragment Approach
por: van der Westhuizen, Leandi, et al.
Publicado: (2022)

Systematic Probing of the Sequence Selectivity of Exonuclease III with a Photosensitization Colorimetric Assay
por: Ding, Yu, et al.
Publicado: (2019)

Catalyst deactivation /
Publicado: (1999)

Pathogenesis of Lassa Fever
por: Yun, Nadezhda E., et al.
Publicado: (2012)

Learning in the Lassa Belt
por: Sandige, Heidi
Publicado: (2018)

Reversible Covalent PROTACs: Novel and Efficient Targeted Degradation Strategy
por: Yuan, Minghua, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_eubs2jl7n6li4ermmlq7uk0j66