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HuR drives lung fibroblast differentiation but not metabolic reprogramming in response to TGF-β and hypoxia
BACKGROUND: Pulmonary fibrosis is thought to be driven by recurrent alveolar epithelial injury which leads to the differentiation of fibroblasts into α-smooth muscle actin (α-SMA)-expressing myofibroblasts and subsequent deposition of extracellular matrix (ECM). Transforming growth factor beta-1 (TG...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715577/ https://www.ncbi.nlm.nih.gov/pubmed/34963461 http://dx.doi.org/10.1186/s12931-021-01916-4 |