Cargando…

Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity

BACKGROUND: Pathological interactions between β-amyloid (Aβ) and tau drive synapse loss and cognitive decline in Alzheimer’s disease (AD). Reactive astrocytes, displaying altered functions, are also a prominent feature of AD brain. This large and heterogeneous population of cells are increasingly re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Perez-Nievas, Beatriz G., Johnson, Louisa, Beltran-Lobo, Paula, Hughes, Martina M., Gammallieri, Luciana, Tarsitano, Francesca, Myszczynska, Monika A., Vazquez-Villasenor, Irina, Jimenez-Sanchez, Maria, Troakes, Claire, Wharton, Stephen B., Ferraiuolo, Laura, Noble, Wendy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8715604/ https://www.ncbi.nlm.nih.gov/pubmed/34963475 http://dx.doi.org/10.1186/s12974-021-02371-0

Ejemplares similares

The reduction of astrocytic tau prevents amyloid-β-induced synaptotoxicity
por: Cisternas, Pablo, et al.
Publicado: (2022)

Astrocytes in Tauopathies
por: Reid, Matthew J., et al.
Publicado: (2020)

Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2
por: Staurenghi, Erica, et al.
Publicado: (2020)

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity
por: Nicoll, Andrew J., et al.
Publicado: (2013)

Amyloid-β Protofibrils: Size, Morphology and Synaptotoxicity of an Engineered Mimic
por: Dubnovitsky, Anatoly, et al.
Publicado: (2013)

Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil
por: Sellers, Katherine J., et al.
Publicado: (2018)

A Foldamer-Dendrimer Conjugate Neutralizes Synaptotoxic β-Amyloid Oligomers
por: Fülöp, Lívia, et al.
Publicado: (2012)

Correction: Amyloid-β Protofibrils: Size, Morphology and Synaptotoxicity of an Engineered Mimic
por: Dubnovitsky, Anatoly, et al.
Publicado: (2013)

STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity
por: Popugaeva, Elena, et al.
Publicado: (2015)

Astrocyte adaptation in Alzheimer’s disease: a focus on astrocytic P2X(7)R
por: Beltran-Lobo, Paula, et al.
Publicado: (2023)

Reactive Astrocytes Contribute to Alzheimer’s Disease-Related Neurotoxicity and Synaptotoxicity in a Neuron-Astrocyte Co-culture Assay
por: Wasilewski, David, et al.
Publicado: (2022)

Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property
por: Sepulveda, Fernando J., et al.
Publicado: (2010)

Andrographolide attenuates LPS-stimulated up-regulation of C-C and C-X-C motif chemokines in rodent cortex and primary astrocytes
por: Wong, Siew Ying, et al.
Publicado: (2016)

Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity
por: Moosecker, Susanne, et al.
Publicado: (2019)

Corrigendum: Activated PPARγ Abrogates Misprocessing of Amyloid Precursor Protein, Tau Missorting and Synaptotoxicity
por: Moosecker, Susanne, et al.
Publicado: (2020)

Cytotoxic chemotherapy reduces T cell trafficking to the spleen by downregulating the expression of C-C motif chemokine ligand 21 and C-C motif chemokine ligand 19
por: Liu, Lina, et al.
Publicado: (2018)

Alzheimer's disease-related amyloid-β induces synaptotoxicity in human iPS cell-derived neurons
por: Nieweg, K, et al.
Publicado: (2015)

Molecular Mechanisms of Synaptotoxicity and Neuroinflammation in Alzheimer’s Disease
por: Marttinen, Mikael, et al.
Publicado: (2018)

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
por: Varcianna, André, et al.
Publicado: (2019)

Potentials of C‐C motif chemokine 2–C‐C chemokine receptor type 2 blockers including propagermanium as anticancer agents
por: Yumimoto, Kanae, et al.
Publicado: (2019)

Chemokine (C-X-C motif) ligand 1/chemokine (C-X-C motif) receptor 2 autocrine loop contributes to cellular proliferation, migration and apoptosis in cervical cancer
por: Sun, Jiping, et al.
Publicado: (2022)

Plasma levels of monokine induced by interferon-gamma/chemokine (C-X-X motif) ligand 9, thymus and activation-regulated chemokine/chemokine (C-C motif) ligand 17 in children with Kawasaki disease
por: Feng, Siqi, et al.
Publicado: (2015)

The Significance of Selected C-C Motif Chemokine Ligands in Colorectal Cancer Patients
por: Zajkowska, Monika, et al.
Publicado: (2022)

Combination of C-X-C motif chemokine 9 and C-X-C motif chemokine 10 antibodies with FTY720 prolongs the survival of cardiac retransplantation allografts in a mouse model
por: MA, TENG, et al.
Publicado: (2015)

A Neuronal Culture System to Detect Prion Synaptotoxicity
por: Fang, Cheng, et al.
Publicado: (2016)

Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders
por: Wang, Yupeng, et al.
Publicado: (2023)

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis
por: Allen, Scott P, et al.
Publicado: (2019)

E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity
por: Suzuki, Takayuki, et al.
Publicado: (2010)

Pyk2 overexpression in postsynaptic neurons blocks amyloid β(1–42)-induced synaptotoxicity in microfluidic co-cultures
por: Kilinc, Devrim, et al.
Publicado: (2020)

Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain
por: Selenica, Maj-Linda B, et al.
Publicado: (2013)

Role of chemokine C-C motif ligand-1 in acute and chronic pulmonary inflammations
por: Kishi, Hiroyuki, et al.
Publicado: (2016)

Expression of C–C motif chemokines and their receptors in bovine placentomes at spontaneous and induced parturition
por: HIRAYAMA, Hiroki, et al.
Publicado: (2019)

Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell‐Derived Chemokine (C‐C Motif) Ligand 2 and Chemokine (C‐X‐C motif) Ligand 1 Contributes to Neointima Formation
por: Yu, Baoqi, et al.
Publicado: (2016)

Ethanol promoting the upregulation of C-X-C Motif Chemokine Ligand 1（CXCL1） and C-X-C Motif Chemokine Ligand 6（CXCL6） in models of early alcoholic liver disease
por: Jiang, Yao, et al.
Publicado: (2022)

Commentary: Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders
por: Zhang, Jingdan, et al.
Publicado: (2023)

Impacts of Chemokine (C-X-C Motif) Receptor 2 C1208T Polymorphism on Cancer Susceptibility
por: Zhou, Jing, et al.
Publicado: (2021)

Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus
por: Dominguez-Gutierrez, Paul R, et al.
Publicado: (2014)

Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
por: Sanchez-Varo, Raquel, et al.
Publicado: (2021)

Reduced expression of chemokine (C-C motif) ligand-2 (CCL2) in ovarian adenocarcinoma
por: Arnold, J M, et al.
Publicado: (2005)

The Effect of C-X-C Motif Chemokine 13 on Hepatocellular Carcinoma Associates with Wnt Signaling
por: Li, Chunyan, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_g7r698ic1aehsqgmn1vt2tu887