Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage

Microenvironmental factors modulating age-related DNA damage are unclear. Non-pituitary growth hormone (npGH) is induced in human colon, non-transformed human colon cells, and fibroblasts, and in 3-dimensional intestinal organoids with age-associated DNA damage. Autocrine/paracrine npGH suppresses p...

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Detalles Bibliográficos
Autores principales: Chesnokova, Vera, Zonis, Svetlana, Apostolou, Athanasia, Estrada, Hannah Q., Knott, Simon, Wawrowsky, Kolja, Michelsen, Kathrin, Ben-Shlomo, Anat, Barrett, Robert, Gorbunova, Vera, Karalis, Katia, Melmed, Shlomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716125/
https://www.ncbi.nlm.nih.gov/pubmed/34910915
http://dx.doi.org/10.1016/j.celrep.2021.110068

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716125/
https://www.ncbi.nlm.nih.gov/pubmed/34910915
http://dx.doi.org/10.1016/j.celrep.2021.110068

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