MEK1/2 Inhibitor (GDC0623) Promotes Osteogenic Differentiation of Primary Osteoblasts Inhibited by IL-1β through the MEK-Erk1/2 and Jak/Stat3 Pathways

OBJECTIVE: We evaluated the effects and mechanisms of GDC0623 on osteogenic differentiation of osteoblasts induced by IL-1β. Methodology. Osteoblasts were treated with 20 ng/ml IL-1β and 0.1 µM GDC0623. Cell proliferation levels were evaluated by the cell counting kit 8 (CCK8), EdU assay, and wester...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Zeng-Qiao, Hu, Xiao-Shen, Lu, Ye-Chen, Zhang, Jun-Peng, Li, Wen-Yao, Zhang, Wei-Yang, Feng, Wei, Ding, Dao-Fang, Xu, Jian-Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716208/
https://www.ncbi.nlm.nih.gov/pubmed/34976051
http://dx.doi.org/10.1155/2021/5720145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716208/
https://www.ncbi.nlm.nih.gov/pubmed/34976051
http://dx.doi.org/10.1155/2021/5720145

Ejemplares similares