Cargando…

VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process with high morbidity and mortality. An important pathophysiological characteristic of LIRI is endothelial barrier dysfunction, although the mechanism involved in this process remains unclear. VX765, a specific caspase-1 i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Siyi, Li, Zhao, Ye, Mengling, Liu, Chunxia, Liu, Hao, He, Xiaojing, Qin, Yi, Liang, Fangte, Pan, Linghui, Lin, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716216/ https://www.ncbi.nlm.nih.gov/pubmed/34977239 http://dx.doi.org/10.1155/2021/4525988

Ejemplares similares

VX‐765 ameliorates renal injury and fibrosis in diabetes by regulating caspase‐1‐mediated pyroptosis and inflammation
por: Wen, Si, et al.
Publicado: (2021)

The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway
por: Do Carmo, Helison, et al.
Publicado: (2018)

VX-765 reduces neuroinflammation after spinal cord injury in mice
por: Chen, Jing, et al.
Publicado: (2021)

Preconditioning with rHMGB1 ameliorates lung ischemia–reperfusion injury by inhibiting alveolar macrophage pyroptosis via the Keap1/Nrf2/HO-1 signaling pathway
por: Fei, Lin, et al.
Publicado: (2020)

Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis
por: Jin, Ying, et al.
Publicado: (2022)

VX765 Attenuates Pyroptosis and HMGB1/TLR4/NF-κB Pathways to Improve Functional Outcomes in TBI Mice
por: Sun, Zhezhe, et al.
Publicado: (2020)

Effect of VX-765 on the transcriptome profile of mice spinal cords with acute injury
por: Chen, Jing, et al.
Publicado: (2020)

VX-765 has a Protective Effect on Mice with Ovarian Injury Caused by Chemotherapy
por: Lee, Pingyin, et al.
Publicado: (2023)

VX-765 Alleviates β-Amyloid Deposition and Secondary Degeneration in the Ipsilateral Hippocampus and Ameliorates Cognitive Decline after Focal Cortical Infarction in Rats
por: Dong, Dawei, et al.
Publicado: (2022)

GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
por: Zhao, Chen, et al.
Publicado: (2023)

Near-infrared laser-irradiated upconversion nanoparticles with dexamethasone precise released for alleviating lung ischemia-reperfusion injury
por: He, Xiaojing, et al.
Publicado: (2023)

Downregulation of SIRT3 Aggravates Lung Ischemia Reperfusion Injury by Increasing Mitochondrial Fission and Oxidative Stress through HIF-1α-Dependent Mechanisms
por: Liu, Chunxia, et al.
Publicado: (2022)

The Role of Pyroptosis and Autophagy in Ischemia Reperfusion Injury
por: Zhao, Huijie, et al.
Publicado: (2022)

Aquaporin 4 inhibition alleviates myocardial ischemia-reperfusion injury by restraining cardiomyocyte pyroptosis
por: Jiang, Qiong, et al.
Publicado: (2021)

Maresin1 alleviates liver ischemia/reperfusion injury by reducing liver macrophage pyroptosis
por: Li, Tong, et al.
Publicado: (2023)

The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4(+) T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice
por: Amand, Mathieu, et al.
Publicado: (2023)

Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes
por: Ye, Bozhi, et al.
Publicado: (2019)

Emodin alleviates lung ischemia–reperfusion injury by suppressing gasdermin D‐mediated pyroptosis in rats
por: Jin, Tao, et al.
Publicado: (2023)

Atractylenolide I alleviates ischemia/reperfusion injury by preserving mitochondrial function and inhibiting caspase-3 activity
por: Sun, Caiqin, et al.
Publicado: (2021)

Inhibition of Caspase-1 Ameliorates Ischemia-Associated Blood-Brain Barrier Dysfunction and Integrity by Suppressing Pyroptosis Activation
por: Liang, Yubin, et al.
Publicado: (2021)

Lung Inflation With Hydrogen During the Cold Ischemia Phase Alleviates Lung Ischemia-Reperfusion Injury by Inhibiting Pyroptosis in Rats
por: Zheng, Panpan, et al.
Publicado: (2021)

Downregulated XBP-1 Rescues Cerebral Ischemia/Reperfusion Injury-Induced Pyroptosis via the NLRP3/Caspase-1/GSDMD Axis
por: Zhang, Yueting, et al.
Publicado: (2022)

Research Progress on the Role of Pyroptosis in Myocardial Ischemia-Reperfusion Injury
por: Liu, Yang, et al.
Publicado: (2022)

IP3R1 regulates Ca(2+) transport and pyroptosis through the NLRP3/Caspase-1 pathway in myocardial ischemia/reperfusion injury
por: Mo, Guixi, et al.
Publicado: (2021)

Andrade-Oliveira Salvianolic Acid B Modulates Caspase-1–Mediated Pyroptosis in Renal Ischemia-Reperfusion Injury via Nrf2 Pathway
por: Pang, Yu, et al.
Publicado: (2020)

Mechanism of Electroacupuncture Against Cerebral Ischemia–Reperfusion Injury: Reducing Inflammatory Response and Cell Pyroptosis by Inhibiting NLRP3 and Caspase-1
por: Cai, Li, et al.
Publicado: (2022)

Sevoflurane Alleviates Myocardial Ischemia Reperfusion Injury by Inhibiting P2X7-NLRP3 Mediated Pyroptosis
por: Wu, Jiaxuan, et al.
Publicado: (2021)

Inhibition of microRNA-122 alleviates pyroptosis by targeting dual-specificity phosphatase 4 in myocardial ischemia/reperfusion injury
por: Wu, Hongjin, et al.
Publicado: (2023)

Inhibition of p38 MAPK Mitigates Lung Ischemia Reperfusion Injury by Reducing Blood–Air Barrier Hyperpermeability
por: Wang, Tiantian, et al.
Publicado: (2020)

Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis
por: Li, Wenlian, et al.
Publicado: (2022)

Administration of troxerutin and cerebroprotein hydrolysate injection alleviates cerebral ischemia/reperfusion injury by down-regulating caspase molecules
por: Sui, Rubo, et al.
Publicado: (2019)

Astragaloside IV Alleviates Cerebral Ischemia-Reperfusion Injury through NLRP3 Inflammasome-Mediated Pyroptosis Inhibition via Activating Nrf2
por: Xiao, Lan, et al.
Publicado: (2021)

Corrigendum: Sevoflurane Alleviates Myocardial Ischemia Reperfusion Injury by Inhibiting P2X7-NLRP3 Mediated Pyroptosis
por: Wu, Jiaxuan, et al.
Publicado: (2022)

Treadmill training attenuates pyroptosis in rats with cerebral ischemia/reperfusion injury
por: Luo, Fang, et al.
Publicado: (2022)

Pyroptosis: A Newly Discovered Therapeutic Target for Ischemia-Reperfusion Injury
por: Zheng, Yu, et al.
Publicado: (2022)

Ellagic acid Alleviates hepatic ischemia–reperfusion injury in C57 mice via the Caspase-1-GSDMD pathway
por: Wang, Hao, et al.
Publicado: (2022)

Artemisinin analog SM934 alleviates epithelial barrier dysfunction via inhibiting apoptosis and caspase-1-mediated pyroptosis in experimental colitis
por: Shao, Meijuan, et al.
Publicado: (2022)

VX‐765 enhances autophagy of human umbilical cord mesenchymal stem cells against stroke‐induced apoptosis and inflammatory responses via AMPK/mTOR signaling pathway
por: Sun, Zhezhe, et al.
Publicado: (2020)

Vagus nerve stimulation alleviated cerebral ischemia and reperfusion injury in rats by inhibiting pyroptosis via α7 nicotinic acetylcholine receptor
por: Tang, Hao, et al.
Publicado: (2022)

Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway
por: Zhang, Banghua, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_djbej74ei7in7o7d9ccooq12sa