Single-Cell Analysis of Target Antigens of CAR-T Reveals a Potential Landscape of “On-Target, Off-Tumor Toxicity”

Cellular immunotherapy represented by CD19-directed chimeric antigen receptor T (CAR-T) cells has achieved great success in recent years. An increasing number of CAR-T therapies are being developed for cancer treatment, but the frequent and varied adverse events, such as “on-target, off-tumor toxici...

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Detalles Bibliográficos
Autores principales: Zhang, Yinyin, Li, Yingmei, Cao, Weijie, Wang, Fang, Xie, Xinsheng, Li, Yadan, Wang, Xiaoyi, Guo, Rong, Jiang, Zhongxing, Guo, Rongqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716389/
https://www.ncbi.nlm.nih.gov/pubmed/34975912
http://dx.doi.org/10.3389/fimmu.2021.799206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716389/
https://www.ncbi.nlm.nih.gov/pubmed/34975912
http://dx.doi.org/10.3389/fimmu.2021.799206

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