Cargando…

DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication

Emerging studies reveal that neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are commonly linked to DNA damage accumulation and repair deficiency. Neurons are particularly vulnerable to DNA damage due to their high metabolic activity, rel...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Haibo, Kodavati, Manohar, Britz, Gavin W., Hegde, Muralidhar L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716463/ https://www.ncbi.nlm.nih.gov/pubmed/34975400 http://dx.doi.org/10.3389/fnmol.2021.784361

Ejemplares similares

lncRNA Sequencing Reveals Neurodegeneration-associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists In Motor Neurons
por: Provasek, Vincent E., et al.
Publicado: (2023)

lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons
por: Provasek, Vincent E., et al.
Publicado: (2023)

New Mechanisms of DNA Repair Defects in Fused in Sarcoma–Associated Neurodegeneration: Stage Set for DNA Repair-Based Therapeutics?
por: Wang, Haibo, et al.
Publicado: (2019)

Editorial: Current Concept and Translational Study in ALS–FTD Spectrum: From Genetics, Neuroinflammation to Neurodegeneration
por: Guo, Wenting, et al.
Publicado: (2022)

Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective
por: Kodavati, Manohar, et al.
Publicado: (2020)

FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration
por: Kodavati, Manohar, et al.
Publicado: (2023)

RT(2) PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease
por: Wang, Haibo, et al.
Publicado: (2019)

Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks
por: Chakraborty, Anirban, et al.
Publicado: (2023)

SARS-CoV-2 and the central nervous system: Emerging insights into hemorrhage-associated neurological consequences and therapeutic considerations
por: Mitra, Joy, et al.
Publicado: (2022)

Breakdown of the central synapses in C9orf72-linked ALS/FTD
por: Ghaffari, Layla T., et al.
Publicado: (2022)

Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease
por: Gelon, Pauline A., et al.
Publicado: (2022)

The era of cryptic exons: implications for ALS-FTD
por: Mehta, Puja R., et al.
Publicado: (2023)

Examining the language and behavioural profile in FTD and ALS-FTD
por: Saxon, Jennifer A, et al.
Publicado: (2017)

Inflammation in ALS/FTD pathogenesis
por: McCauley, Madelyn E., et al.
Publicado: (2018)

A Peptidylic Inhibitor for Neutralizing (r)(GGGGCC)(exp)-Associated Neurodegeneration in C9ALS-FTD
por: Zhang, Qian, et al.
Publicado: (2019)

RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3
por: Ramesh, Nandini, et al.
Publicado: (2020)

Nucleotide Salvage Deficiencies, DNA Damage and Neurodegeneration
por: Fasullo, Michael, et al.
Publicado: (2015)

Genetic screening in sporadic ALS and FTD
por: Turner, Martin R, et al.
Publicado: (2017)

Motor Neuron Susceptibility in ALS/FTD
por: Ragagnin, Audrey M. G., et al.
Publicado: (2019)

Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD
por: Tang, Xiaoqiang, et al.
Publicado: (2020)

Autophagy and neurodegeneration: Unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology
por: Diab, Rim, et al.
Publicado: (2023)

Disease Mechanisms and Therapeutic Approaches in C9orf72 ALS-FTD
por: Mayl, Keith, et al.
Publicado: (2021)

Graph theory network analysis provides brain MRI evidence of a partial continuum of neurodegeneration in patients with UMN-predominant ALS and ALS-FTD
por: Rajagopalan, Venkateswaran, et al.
Publicado: (2022)

Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription
por: Sengupta, Shiladitya, et al.
Publicado: (2020)

Human DNA Glycosylase NEIL1’s Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival
por: Hegde, Muralidhar L., et al.
Publicado: (2012)

Correction to: Divergence, Convergence, and Therapeutic Implications: A Cell Biology Perspective of C9ORF72-ALS/FTD
por: Tang, Xiaoqiang, et al.
Publicado: (2020)

The role of inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD
por: Masrori, Pegah, et al.
Publicado: (2022)

Erratum: Autophagy and neurodegeneration: unraveling the role of C9ORF72 in the regulation of autophagy and its relationship to ALS-FTD pathology
Publicado: (2023)

Recruitment of DNA repair synthesis machinery to sites of DNA damage/repair in living human cells
por: Hashiguchi, Kazunari, et al.
Publicado: (2007)

Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis
por: Wang, Haibo, et al.
Publicado: (2018)

New Perspectives on Oxidized Genome Damage and Repair Inhibition by Pro-Oxidant Metals in Neurological Diseases
por: Mitra, Joy, et al.
Publicado: (2014)

Epigenetic Small Molecules Rescue Nucleocytoplasmic Transport and DNA Damage Phenotypes in C9ORF72 ALS/FTD
por: Ramic, Melina, et al.
Publicado: (2021)

DNA Damage, Defective DNA Repair, and Neurodegeneration in Amyotrophic Lateral Sclerosis
por: Konopka, Anna, et al.
Publicado: (2022)

Cognitive and behavioral features of c9FTD/ALS
por: Boeve, Bradley F, et al.
Publicado: (2012)

Linking hnRNP Function to ALS and FTD Pathology
por: Purice, Maria D., et al.
Publicado: (2018)

Lipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders
por: Godoy-Corchuelo, Juan Miguel, et al.
Publicado: (2022)

ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion
por: Henderson, Robert David, et al.
Publicado: (2022)

Neural circuit and synaptic dysfunctions in ALS-FTD pathology
por: Mora, Santiago, et al.
Publicado: (2023)

Editorial: Cancer Therapeutics: Targeting DNA Repair Pathways
por: Suraweera, Amila, et al.
Publicado: (2022)

Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
por: Leung, Emily, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_htocfdp7ppnjp51l31gadt3k1i