Progressive Microstructural Deterioration Dictates Evolving Biomechanical Dysfunction in the Marfan Aorta

Medial deterioration leading to thoracic aortic aneurysms arises from multiple causes, chief among them mutations to the gene that encodes fibrillin-1 and leads to Marfan syndrome. Fibrillin-1 microfibrils associate with elastin to form elastic fibers, which are essential structural, functional, and...

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Detalles Bibliográficos
Autores principales: Cavinato, Cristina, Chen, Minghao, Weiss, Dar, Ruiz-Rodríguez, Maria Jesús, Schwartz, Martin A., Humphrey, Jay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716484/
https://www.ncbi.nlm.nih.gov/pubmed/34977201
http://dx.doi.org/10.3389/fcvm.2021.800730

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716484/
https://www.ncbi.nlm.nih.gov/pubmed/34977201
http://dx.doi.org/10.3389/fcvm.2021.800730

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