Embeddings from protein language models predict conservation and variant effects

The emergence of SARS-CoV-2 variants stressed the demand for tools allowing to interpret the effect of single amino acid variants (SAVs) on protein function. While Deep Mutational Scanning (DMS) sets continue to expand our understanding of the mutational landscape of single proteins, the results con...

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Detalles Bibliográficos
Autores principales: Marquet, Céline, Heinzinger, Michael, Olenyi, Tobias, Dallago, Christian, Erckert, Kyra, Bernhofer, Michael, Nechaev, Dmitrii, Rost, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716573/
https://www.ncbi.nlm.nih.gov/pubmed/34967936
http://dx.doi.org/10.1007/s00439-021-02411-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716573/
https://www.ncbi.nlm.nih.gov/pubmed/34967936
http://dx.doi.org/10.1007/s00439-021-02411-y

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