Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients

BACKGROUND: Tumour hypoxia promotes an aggressive tumour phenotype and enhances resistance to anticancer treatments. Following the recent observation that the mitochondrial inhibitor atovaquone increases tumour oxygenation in NSCLC, we sought to assess whether atovaquone affects tumour subregions di...

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Detalles Bibliográficos
Autores principales: Bourigault, Pauline, Skwarski, Michael, Macpherson, Ruth E., Higgins, Geoff S., McGowan, Daniel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716680/
https://www.ncbi.nlm.nih.gov/pubmed/34964932
http://dx.doi.org/10.1186/s13550-021-00871-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716680/
https://www.ncbi.nlm.nih.gov/pubmed/34964932
http://dx.doi.org/10.1186/s13550-021-00871-x

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