Phenotypic Variability in iPSC-Induced Cardiomyocytes and Cardiac Fibroblasts Carrying Diverse LMNA Mutations

Mutations in the LMNA gene (encoding lamin A/C) are a significant cause of familial arrhythmogenic cardiomyopathy. Although the penetrance is high, there is considerable phenotypic variability in disease onset, rate of progression, arrhythmias, and severity of myopathy. To begin to address whether t...

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Detalles Bibliográficos
Autores principales: Yang, Jiajia, Argenziano, Mariana A., Burgos Angulo, Mariana, Bertalovitz, Alexander, Beidokhti, Maliheh Najari, McDonald, Thomas V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716763/
https://www.ncbi.nlm.nih.gov/pubmed/34975533
http://dx.doi.org/10.3389/fphys.2021.778982

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716763/
https://www.ncbi.nlm.nih.gov/pubmed/34975533
http://dx.doi.org/10.3389/fphys.2021.778982

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