SKI‐G‐801, an AXL kinase inhibitor, blocks metastasis through inducing anti‐tumor immune responses and potentiates anti‐PD‐1 therapy in mouse cancer models

OBJECTIVES: AXL‐mediated activation of aberrant tyrosine kinase drives various oncogenic processes and facilitates an immunosuppressive microenvironment. We evaluated the anti‐tumor and anti‐metastatic activities of SKI‐G‐801, a small‐molecule inhibitor of AXL, alone and in combination with anti‐PD‐...

Descripción completa

Detalles Bibliográficos
Autores principales: Synn, Chun‐Bong, Kim, Sung Eun, Lee, Hee Kyu, Kim, Min‐Hwan, Kim, Jae Hwan, Lee, Ji Min, Jo, Ha Ni, Lee, Wongeun, Kim, Dong Kwon, Byeon, Youngseon, Kim, Young Seob, Yun, Mi Ran, Park, Chae‐Won, Yun, Jiyeon, Lim, Sangbin, Heo, Seong Gu, Yang, San‐Duk, Lee, Eun Ji, Lee, Seul, Choi, Hunmi, Lee, You Won, Cho, Jae Seok, Kim, Do Hee, Park, Sungho, Kim, Jung‐Ho, Choi, Yewon, Lee, Sung Sook, Ahn, Beung‐Chul, Kim, Chang Gon, Lim, Sun Min, Hong, Min Hee, Kim, Hye Ryun, Pyo, Kyoung‐Ho, Cho, Byoung Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716998/
https://www.ncbi.nlm.nih.gov/pubmed/35003748
http://dx.doi.org/10.1002/cti2.1364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8716998/
https://www.ncbi.nlm.nih.gov/pubmed/35003748
http://dx.doi.org/10.1002/cti2.1364

Ejemplares similares