Charge Engineering Reveals the Roles of Ionizable Side Chains in Electrospray Ionization Mass Spectrometry

[Image: see text] In solution, the charge of a protein is intricately linked to its stability, but electrospray ionization distorts this connection, potentially limiting the ability of native mass spectrometry to inform about protein structure and dynamics. How the behavior of intact proteins in the...

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Detalles Bibliográficos
Autores principales: Abramsson, Mia L., Sahin, Cagla, Hopper, Jonathan T. S., Branca, Rui M. M., Danielsson, Jens, Xu, Mingming, Chandler, Shane A., Österlund, Nicklas, Ilag, Leopold L., Leppert, Axel, Costeira-Paulo, Joana, Lang, Lisa, Teilum, Kaare, Laganowsky, Arthur, Benesch, Justin L. P., Oliveberg, Mikael, Robinson, Carol V., Marklund, Erik G., Allison, Timothy M., Winther, Jakob R., Landreh, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717373/
https://www.ncbi.nlm.nih.gov/pubmed/34977906
http://dx.doi.org/10.1021/jacsau.1c00458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717373/
https://www.ncbi.nlm.nih.gov/pubmed/34977906
http://dx.doi.org/10.1021/jacsau.1c00458

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