URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice

OBJECTIVE: Accumulating evidence indicates that high uric acid (UA) is strongly associated with obesity and metabolic syndrome and drives the development of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Although urate transporter-1 (URAT1), which is primarily expressed in the kidn...

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Detalles Bibliográficos
Autores principales: Tanaka, Yoshiro, Nagoshi, Tomohisa, Takahashi, Hirotake, Oi, Yuhei, Yoshii, Akira, Kimura, Haruka, Ito, Keiichi, Kashiwagi, Yusuke, Tanaka, Toshikazu D., Yoshimura, Michihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717577/
https://www.ncbi.nlm.nih.gov/pubmed/34863940
http://dx.doi.org/10.1016/j.molmet.2021.101411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717577/
https://www.ncbi.nlm.nih.gov/pubmed/34863940
http://dx.doi.org/10.1016/j.molmet.2021.101411

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