Cargando…

URAT1-selective inhibition ameliorates insulin resistance by attenuating diet-induced hepatic steatosis and brown adipose tissue whitening in mice

OBJECTIVE: Accumulating evidence indicates that high uric acid (UA) is strongly associated with obesity and metabolic syndrome and drives the development of nonalcoholic fatty liver disease (NAFLD) and insulin resistance. Although urate transporter-1 (URAT1), which is primarily expressed in the kidn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tanaka, Yoshiro, Nagoshi, Tomohisa, Takahashi, Hirotake, Oi, Yuhei, Yoshii, Akira, Kimura, Haruka, Ito, Keiichi, Kashiwagi, Yusuke, Tanaka, Toshikazu D., Yoshimura, Michihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717577/ https://www.ncbi.nlm.nih.gov/pubmed/34863940 http://dx.doi.org/10.1016/j.molmet.2021.101411

Ejemplares similares

Treatment with atrial natriuretic peptide induces adipose tissue browning and exerts thermogenic actions in vivo
por: Kimura, Haruka, et al.
Publicado: (2021)

URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease
por: Tanaka, Yoshiro, et al.
Publicado: (2023)

Exogenous ANP Treatment Ameliorates Myocardial Insulin Resistance and Protects against Ischemia–Reperfusion Injury in Diet-Induced Obesity
por: Oi, Yuhei, et al.
Publicado: (2022)

Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes
por: Takahashi, Hirotake, et al.
Publicado: (2022)

The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe
por: Kimura, Haruka, et al.
Publicado: (2017)

Cardiac ischemia–reperfusion injury under insulin-resistant conditions: SGLT1 but not SGLT2 plays a compensatory protective role in diet-induced obesity
por: Yoshii, Akira, et al.
Publicado: (2019)

Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure
por: Takahashi, Hirotake, et al.
Publicado: (2021)

Close linkage between blood total ketone body levels and B-type natriuretic peptide levels in patients with cardiovascular disorders
por: Kashiwagi, Yusuke, et al.
Publicado: (2021)

Effects of angiotensin receptor‐neprilysin inhibitor on insulin resistance in patients with heart failure
por: Kashiwagi, Yusuke, et al.
Publicado: (2023)

Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis
por: Ito, Satoshi, et al.
Publicado: (2017)

Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
por: Tanaka, Yoshiro, et al.
Publicado: (2017)

Collaborative Activities of Noradrenaline and Natriuretic Peptide for Glucose Utilization in Patients with Acute Coronary Syndrome
por: Uno, Goki, et al.
Publicado: (2019)

Expression of SGLT1 in Human Hearts and Impairment of Cardiac Glucose Uptake by Phlorizin during Ischemia-Reperfusion Injury in Mice
por: Kashiwagi, Yusuke, et al.
Publicado: (2015)

Coronary artery disease concomitant with immunoglobulin G4-related disease: a case report and literature review
por: Okuyama, Toraaki, et al.
Publicado: (2019)

Heart Failure Treatments Such As Angiotensin Receptor/Neprilysin Inhibitor Improve Heart Failure Status and Glucose Metabolism
por: Kashiwagi, Yusuke, et al.
Publicado: (2022)

Parallel comparison of risk factors between progression of organic stenosis in the coronary arteries and onset of acute coronary syndrome by covariance structure analysis
por: Ogawa, Kazuo, et al.
Publicado: (2017)

Increase in the oxidised low-density lipoprotein level by smoking and the possible inhibitory effect of statin therapy in patients with cardiovascular disease: a retrospective study
por: Ogawa, Kazuo, et al.
Publicado: (2015)

Therapeutic hypothermia after cardiac arrest increases the plasma level of B-type natriuretic peptide
por: Kashiwagi, Yusuke, et al.
Publicado: (2020)

Constrictive Pericarditis with Cardiac Ascites Caused Spontaneous Bacterial Peritonitis
por: Kashiwagi, Yusuke, et al.
Publicado: (2021)

High Serum Uric Acid is Highly Associated with a Reduced Left Ventricular Ejection Fraction Rather than Increased Plasma B-type Natriuretic Peptide in Patients with Cardiovascular Diseases
por: Oki, Yoshitsugu, et al.
Publicado: (2019)

Association between plasma B-type natriuretic peptide and anaemia in heart failure with or without ischaemic heart disease: a retrospective study
por: Tominaga, Mitsutoshi, et al.
Publicado: (2019)

Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor
por: Tsutsumi, Joshi, et al.
Publicado: (2017)

A Pilot Evaluation Study of Diffuse Coronary Arterial Contraction Causing Ischemia by Double Measurement of Left Ventriculography Before and After Intracoronary Administration of Nitrates
por: Minai, Kosuke, et al.
Publicado: (2021)

Rate of atmospheric brown carbon whitening governed by environmental conditions
por: Schnitzler, Elijah G., et al.
Publicado: (2022)

Protease activated receptor-1, but not -2, -3 and -4, is the player in the pathogenesis of atrial fibrosis; The experiment by neonatal rat atrial fibroblasts
por: Ito, Keiichi, et al.
Publicado: (2013)

Successful treatment of pulmonary hypertension following hematopoietic stem cell transplant with a single oral tadalafil: a case report
por: Tanaka, Toshikazu D., et al.
Publicado: (2021)

Conflicting relationship between age-dependent disorders, valvular heart disease and coronary artery disease by covariance structure analysis: Possible contribution of natriuretic peptide
por: Fukumoto, Risa, et al.
Publicado: (2017)

Unique crosstalk between platelet and leukocyte counts during treatment for acute coronary syndrome: A retrospective observational study
por: Shirasaki, Keisuke, et al.
Publicado: (2022)

SUN-590 27-Hydroxycholesterol Triggers the Whitening of Brown Adipose Tissue
por: Asghari, Arvand, et al.
Publicado: (2020)

Whitening Effect of Black Tea Water Extract on Brown Guinea Pig Skin
por: Choi, So-Young, et al.
Publicado: (2011)

Impact of Exercise and Detraining during Childhood on Brown Adipose Tissue Whitening in Obesity
por: Takaishi, Kaho, et al.
Publicado: (2021)

Rapid Induction of Aldosterone Synthesis in Cultured Neonatal Rat Cardiomyocytes under High Glucose Conditions
por: Fujisaki, Masami, et al.
Publicado: (2013)

Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis
por: Hiramitsu, Masanori, et al.
Publicado: (2014)

TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality
por: Sass, Frederike, et al.
Publicado: (2021)

Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
por: Pan, Xiao-Xi, et al.
Publicado: (2021)

Obeticholic acid ameliorates obesity and hepatic steatosis by activating brown fat
por: Zhang, Hanlin, et al.
Publicado: (2021)

Treatment Durations and Whitening Outcomes of Different Tooth Whitening Systems
por: Zhao, Xiaoyi, et al.
Publicado: (2023)

Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions
por: Li, Lei, et al.
Publicado: (2022)

An insight into brown/beige adipose tissue whitening, a metabolic complication of obesity with the multifactorial origin
por: Ziqubu, Khanyisani, et al.
Publicado: (2023)

The role of Na(+)/H(+ )exchanger in Ca(2+ )overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice
por: Anzawa, Ryuko, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_a8ca9geg6f1qg1h5c8mvvv1vna