Phenotype Screening of an Azole-bisindole Chemical Library Identifies URB1483 as a New Antileishmanial Agent Devoid of Toxicity on Human Cells

[Image: see text] We report the evaluation of a small library of azole-bisindoles for their antileishmanial potential, in terms of efficacy on Leishmania infantum promastigotes and intracellular amastigotes. Nine compounds showed good activity on L. infantum MHOM/TN/80/IPT1 promastigotes with IC(50)...

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Detalles Bibliográficos
Autores principales: Diotallevi, Aurora, Scalvini, Laura, Buffi, Gloria, Pérez-Pertejo, Yolanda, De Santi, Mauro, Verboni, Michele, Favi, Gianfranco, Magnani, Mauro, Lodola, Alessio, Lucarini, Simone, Galluzzi, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717589/
https://www.ncbi.nlm.nih.gov/pubmed/34984300
http://dx.doi.org/10.1021/acsomega.1c05611

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717589/
https://www.ncbi.nlm.nih.gov/pubmed/34984300
http://dx.doi.org/10.1021/acsomega.1c05611

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