Molecular rationale for the impairment of the MexAB-OprM efflux pump by a single mutation in MexA

Efflux pumps of the Resistance-Nodulation-cell Division (RND) superfamily contribute to intrinsic and acquired resistance in Gram-negative pathogens by expelling chemically unrelated antibiotics with high efficiency. They are tripartite systems constituted by an inner-membrane-anchored transporter,...

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Detalles Bibliográficos
Autores principales: Cacciotto, Pierpaolo, Basciu, Andrea, Oliva, Francesco, Malloci, Giuliano, Zacharias, Martin, Ruggerone, Paolo, Vargiu, Attilio V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717590/
https://www.ncbi.nlm.nih.gov/pubmed/35024097
http://dx.doi.org/10.1016/j.csbj.2021.11.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8717590/
https://www.ncbi.nlm.nih.gov/pubmed/35024097
http://dx.doi.org/10.1016/j.csbj.2021.11.042

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