Inhibition of the NLRP3/IL‐1β axis protects against sepsis‐induced cardiomyopathy

BACKGROUND: Septic cardiomyopathy worsens the prognosis of critically ill patients. Clinical data suggest that interleukin‐1β (IL‐1β), activated by the NLRP3 inflammasome, compromises cardiac function. Whether or not deleting Nlrp3 would prevent cardiac atrophy and improve diastolic cardiac function...

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Detalles Bibliográficos
Autores principales: Busch, Katharina, Kny, Melanie, Huang, Nora, Klassert, Tilman E., Stock, Magdalena, Hahn, Alexander, Graeger, Sebastian, Todiras, Mihail, Schmidt, Sibylle, Chamling, Bishwas, Willenbrock, Michael, Groß, Stefan, Biedenweg, Doreen, Heuser, Arnd, Scheidereit, Claus, Butter, Christian, Felix, Stephan B., Otto, Oliver, Luft, Friedrich C., Slevogt, Hortense, Fielitz, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718055/
https://www.ncbi.nlm.nih.gov/pubmed/34472725
http://dx.doi.org/10.1002/jcsm.12763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718055/
https://www.ncbi.nlm.nih.gov/pubmed/34472725
http://dx.doi.org/10.1002/jcsm.12763

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