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Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations

BACKGROUND: Ageing and cachexia cause a loss of muscle mass over time, indicating that protein breakdown exceeds protein synthesis. Deuterium oxide (D(2)O) is used for studies of protein turnover because of the advantages of long‐term labelling, but these methods introduce considerations that have b...

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Detalles Bibliográficos
Autores principales: Kobak, Kamil A., Lawrence, Marcus M., Pharaoh, Gavin, Borowik, Agnieszka K., Peelor, Frederick F., Shipman, Patrick D., Griffin, Timothy M., Van Remmen, Holly, Miller, Benjamin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718081/
https://www.ncbi.nlm.nih.gov/pubmed/34418329
http://dx.doi.org/10.1002/jcsm.12772