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Calcium-/Calmodulin-Dependent Protein Kinase II (CaMKII) Inhibition Induces Learning and Memory Impairment and Apoptosis

OBJECTIVES: Inhibition of calcium-/calmodulin- (CaM-) dependent kinase II (CaMKII) is correlated with epilepsy. However, the specific mechanism that underlies learning and memory impairment and neuronal death by CaMKII inhibition remains unclear. MATERIALS AND METHODS: In this study, KN93, a CaMKII...

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Detalles Bibliográficos
Autores principales: Wang, Jialu, Xu, Xiaoxue, Jia, Wanying, Zhao, Dongyi, Boczek, Tomasz, Gao, Qinghua, Wang, Qianhui, Fu, Yu, He, Miao, Shi, Ruixue, Tong, Xin, Li, Meixuan, Tong, Yu, Min, Dongyu, Wang, Wuyang, Guo, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718318/
https://www.ncbi.nlm.nih.gov/pubmed/34976299
http://dx.doi.org/10.1155/2021/4635054