Brain Permeable AMP-Activated Protein Kinase Activator R481 Raises Glycaemia by Autonomic Nervous System Activation and Amplifies the Counterregulatory Response to Hypoglycaemia in Rats

AIM: We evaluated the efficacy of a novel brain permeable “metformin-like” AMP-activated protein kinase activator, R481, in regulating glucose homeostasis. MATERIALS AND METHODS: We used glucose sensing hypothalamic GT1-7 neuronal cells and pancreatic αTC1.9 α-cells to examine the effect of R481 on...

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Detalles Bibliográficos
Autores principales: Cruz, Ana M., Partridge, Katie M., Malekizadeh, Yasaman, Vlachaki Walker, Julia M., Weightman Potter, Paul G., Pye, Katherine R., Shaw, Simon J., Ellacott, Kate L. J., Beall, Craig
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718766/
https://www.ncbi.nlm.nih.gov/pubmed/34975743
http://dx.doi.org/10.3389/fendo.2021.697445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718766/
https://www.ncbi.nlm.nih.gov/pubmed/34975743
http://dx.doi.org/10.3389/fendo.2021.697445

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