GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors

The HIV-1 capsid is the target for the antiviral drugs GS-CA1 and Lenacapavir (GS-6207). We investigated the mechanism by which GS-CA1 and GS-6207 inhibit HIV-1 infection. HIV-1 inhibition by GS-CA1 did not require CPSF6 in CD4(+) T cells. Contrary to PF74 that accelerates uncoating of HIV-1, GS-CA1...

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Detalles Bibliográficos
Autores principales: Selyutina, Anastasia, Hu, Pan, Miller, Sorin, Simons, Lacy M., Yu, Hyun Jae, Hultquist, Judd F., Lee, KyeongEun, KewalRamani, Vineet N., Diaz-Griffero, Felipe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718827/
https://www.ncbi.nlm.nih.gov/pubmed/35005542
http://dx.doi.org/10.1016/j.isci.2021.103593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718827/
https://www.ncbi.nlm.nih.gov/pubmed/35005542
http://dx.doi.org/10.1016/j.isci.2021.103593

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