Cargando…

GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors

The HIV-1 capsid is the target for the antiviral drugs GS-CA1 and Lenacapavir (GS-6207). We investigated the mechanism by which GS-CA1 and GS-6207 inhibit HIV-1 infection. HIV-1 inhibition by GS-CA1 did not require CPSF6 in CD4(+) T cells. Contrary to PF74 that accelerates uncoating of HIV-1, GS-CA1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Selyutina, Anastasia, Hu, Pan, Miller, Sorin, Simons, Lacy M., Yu, Hyun Jae, Hultquist, Judd F., Lee, KyeongEun, KewalRamani, Vineet N., Diaz-Griffero, Felipe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718827/ https://www.ncbi.nlm.nih.gov/pubmed/35005542 http://dx.doi.org/10.1016/j.isci.2021.103593

Ejemplares similares

Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
por: Selyutina, Anastasia, et al.
Publicado: (2020)

Formation of nuclear CPSF6/CPSF5 biomolecular condensates upon HIV-1 entry into the nucleus is important for productive infection
por: Luchsinger, Charlotte, et al.
Publicado: (2023)

The HIV-1 capsid core is an opportunistic nuclear import receptor
por: Xue, Guangai, et al.
Publicado: (2023)

TRIM5α Restriction of HIV-1-N74D Viruses in Lymphocytes Is Caused by a Loss of Cyclophilin A Protection
por: Selyutina, Anastasia, et al.
Publicado: (2022)

Perturbation of the P-Body Component Mov10 Inhibits HIV-1 Infectivity
por: Furtak, Vyacheslav, et al.
Publicado: (2010)

Biochemical detection of capsid in the nucleus during HIV-1 infection
por: Selyutina, Anastasia, et al.
Publicado: (2021)

CPSF6 Defines a Conserved Capsid Interface that Modulates HIV-1 Replication
por: Price, Amanda J., et al.
Publicado: (2012)

Lenacapavir: First Approval
por: Paik, Julia
Publicado: (2022)

Caging the Beast: TRIM5α Binding to the HIV-1 Core
por: Diaz-Griffero, Felipe
Publicado: (2011)

Cytokine Signals Are Sufficient for HIV-1 Infection of Resting Human T Lymphocytes
por: Unutmaz, Derya, et al.
Publicado: (1999)

Correction to: Lenacapavir: First Approval
por: Paik, Julia
Publicado: (2023)

Trans-dominant cellular inhibition of DC-SIGN-mediated HIV-1 transmission
por: Wu, Li, et al.
Publicado: (2004)

Nuclear restriction of HIV-1 infection by SUN1
por: Persaud, Mirjana, et al.
Publicado: (2021)

FEZ1 phosphorylation regulates HSPA8 localization and interferon-stimulated gene expression
por: Malikov, Viacheslav, et al.
Publicado: (2022)

Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir
por: Bester, Stephanie M., et al.
Publicado: (2022)

BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 Capsid
por: Fricke, Thomas, et al.
Publicado: (2014)

HIV-1 Capsid-Cyclophilin Interactions Determine Nuclear Import Pathway, Integration Targeting and Replication Efficiency
por: Schaller, Torsten, et al.
Publicado: (2011)

Drug Interactions in Lenacapavir-Based Long-Acting Antiviral Combinations
por: Cilento, Maria E., et al.
Publicado: (2022)

A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats
por: Winans, Shelby, et al.
Publicado: (2022)

MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1
por: Fricke, Thomas, et al.
Publicado: (2014)

Core excitation in $^{11}Be_{gs}$ via the $p(^{11}Be, ^{10}Be)d$ reaction
por: Fortier, S, et al.
Publicado: (1999)

Lenacapavir with Fostemsavir in a Multidrug-Resistant HIV-Infected Hemodialysis Patient
por: Bigirimana, Ferdinand, et al.
Publicado: (2023)

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration
por: Li, Wen, et al.
Publicado: (2020)

HIV Capsid Protein Genetic Diversity Across HIV-1 Variants and Impact on New Capsid-Inhibitor Lenacapavir
por: Troyano-Hernáez, Paloma, et al.
Publicado: (2022)

Nup153 and Nup98 bind the HIV-1 core and contribute to the early steps of HIV-1 replication
por: Di Nunzio, Francesca, et al.
Publicado: (2013)

Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo
por: Michel, Nico, et al.
Publicado: (2009)

Long-acting lenacapavir protects macaques against intravenous challenge with simian-tropic HIV
por: Swanstrom, Adrienne E., et al.
Publicado: (2023)

Live imaging of the airway epithelium reveals that mucociliary clearance modulates SARS-CoV-2 spread
por: Hope, Thomas, et al.
Publicado: (2023)

The Generic Short Patient Experiences Questionnaire (GS-PEQ): identification of core items from a survey in Norway
por: Sjetne, Ingeborg Strømseng, et al.
Publicado: (2011)

73. Interim Resistance Analysis of Long-Acting Lenacapavir in Treatment-Naïve People with HIV at 28 Weeks
por: VanderVeen, Laurie, et al.
Publicado: (2021)

Long-acting lenacapavir acts as an effective preexposure prophylaxis in a rectal SHIV challenge macaque model
por: Bekerman, Elena, et al.
Publicado: (2023)

1581. Weight and Metabolic Changes with Long-Acting Lenacapavir in a Combination Regimen in Treatment-Naïve People with HIV-1 at Week 80
por: Kumar, Princy N, et al.
Publicado: (2023)

Highlights on the Development, Related Patents, and Prospects of Lenacapavir: The First-in-Class HIV-1 Capsid Inhibitor for the Treatment of Multi-Drug-Resistant HIV-1 Infection
por: Dzinamarira, Tafadzwa, et al.
Publicado: (2023)

Core outcome measures in perioperative and anaesthetic care
por: Boney, Oliver, et al.
Publicado: (2015)

Core Java 1.1 /
por: Horstmann, Cay S., 1959-
Publicado: (1997)

Rotten to the core: antivirals targeting the HIV-1 capsid core
por: McFadden, William M., et al.
Publicado: (2021)

GS-CA Compounds: First-In-Class HIV-1 Capsid Inhibitors Covering Multiple Grounds
por: Singh, Kamal, et al.
Publicado: (2019)

Sec24C is an HIV-1 host dependency factor crucial for virus replication
por: Rebensburg, Stephanie V., et al.
Publicado: (2021)

Core Java 1.2
por: Horstmann, Cay S., 1959-
Publicado: (1999)

VSV-G pseudotyping rescues HIV-1 CA mutations that impair core assembly or stability
por: Brun, Sonia, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_sp0o6qmb8fjqus59jsqsblaps8