Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors

The 30+ unique ligands of the TGFβ family signal by forming complexes using different combinations of type I and type II receptors. Therapeutically, the extracellular domain of a single receptor fused to an Fc molecule can effectively neutralize subsets of ligands. Increased ligand specificity can b...

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Detalles Bibliográficos
Autores principales: Goebel, Erich J., Kattamuri, Chandramohan, Gipson, Gregory R., Krishnan, Lavanya, Chavez, Moises, Czepnik, Magdalena, Maguire, Michelle C., Grenha, Rosa, Håkansson, Maria, Logan, Derek T., Grinberg, Asya V., Sako, Dianne, Castonguay, Roselyne, Kumar, Ravindra, Thompson, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718839/
https://www.ncbi.nlm.nih.gov/pubmed/35005539
http://dx.doi.org/10.1016/j.isci.2021.103590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718839/
https://www.ncbi.nlm.nih.gov/pubmed/35005539
http://dx.doi.org/10.1016/j.isci.2021.103590

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