Engineering of the Recombinant Expression and PEGylation Efficiency of the Therapeutic Enzyme Human Thymidine Phosphorylase

Human thymidine phosphorylase (HsTP) is an enzyme with important implications in the field of rare metabolic diseases. Defective mutations of HsTP lead to mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), a disease with a high unmet medical need that is associated with severe neurologic...

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Detalles Bibliográficos
Autores principales: Karamitros, Christos S., Somody, Catrina M., Agnello, Giulia, Rowlinson, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718881/
https://www.ncbi.nlm.nih.gov/pubmed/34976980
http://dx.doi.org/10.3389/fbioe.2021.793985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718881/
https://www.ncbi.nlm.nih.gov/pubmed/34976980
http://dx.doi.org/10.3389/fbioe.2021.793985

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