Shining a light on autophagy in neurodegenerative diseases

Small-molecule modulators of autophagy have been widely investigated as potential therapies for neurodegenerative diseases. In a recent issue of JBC, Safren et al. described a novel assay that uses a photoconvertible fusion protein to identify compounds that alter autophagic flux. Autophagy inducers...

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Detalles Bibliográficos
Autores principales: Chandran, Aswathy, Rochet, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Editors' Pick Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718947/
https://www.ncbi.nlm.nih.gov/pubmed/34801556
http://dx.doi.org/10.1016/j.jbc.2021.101437
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author Chandran, Aswathy
Rochet, Jean-Christophe
author_facet Chandran, Aswathy
Rochet, Jean-Christophe
author_sort Chandran, Aswathy
collection PubMed
description Small-molecule modulators of autophagy have been widely investigated as potential therapies for neurodegenerative diseases. In a recent issue of JBC, Safren et al. described a novel assay that uses a photoconvertible fusion protein to identify compounds that alter autophagic flux. Autophagy inducers identified using this assay were found to either alleviate or exacerbate neurotoxicity in different cellular models of amyotrophic lateral sclerosis, challenging the notion that autophagy stimulation can be used as a one-size-fits-all therapy for neurodegenerative disease.
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spelling pubmed-87189472022-01-07 Shining a light on autophagy in neurodegenerative diseases Chandran, Aswathy Rochet, Jean-Christophe J Biol Chem Editors' Pick Highlight Small-molecule modulators of autophagy have been widely investigated as potential therapies for neurodegenerative diseases. In a recent issue of JBC, Safren et al. described a novel assay that uses a photoconvertible fusion protein to identify compounds that alter autophagic flux. Autophagy inducers identified using this assay were found to either alleviate or exacerbate neurotoxicity in different cellular models of amyotrophic lateral sclerosis, challenging the notion that autophagy stimulation can be used as a one-size-fits-all therapy for neurodegenerative disease. American Society for Biochemistry and Molecular Biology 2021-11-19 /pmc/articles/PMC8718947/ /pubmed/34801556 http://dx.doi.org/10.1016/j.jbc.2021.101437 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editors' Pick Highlight
Chandran, Aswathy
Rochet, Jean-Christophe
Shining a light on autophagy in neurodegenerative diseases
title Shining a light on autophagy in neurodegenerative diseases
title_full Shining a light on autophagy in neurodegenerative diseases
title_fullStr Shining a light on autophagy in neurodegenerative diseases
title_full_unstemmed Shining a light on autophagy in neurodegenerative diseases
title_short Shining a light on autophagy in neurodegenerative diseases
title_sort shining a light on autophagy in neurodegenerative diseases
topic Editors' Pick Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8718947/
https://www.ncbi.nlm.nih.gov/pubmed/34801556
http://dx.doi.org/10.1016/j.jbc.2021.101437
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