Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and re-sensitizes acute myeloid leukemia to BCL-2 inhibition

MCL-1 and BCL-2 are both frequently overexpressed in acute myeloid leukemia (AML) and critical for the survival of AML cells and AML stem cells. MCL-1 is a key factor in venetoclax resistance. Using genetic and pharmacological approaches, we discovered that MCL-1 regulates leukemia cell bioenergetic...

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Detalles Bibliográficos
Autores principales: Carter, Bing Z., Mak, Po Yee, Tao, Wenjing, Warmoes, Marc, Lorenzi, Philip L., Mak, Duncan, Ruvolo, Vivian, Tan, Lin, Cidado, Justin, Drew, Lisa, Andreeff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719086/
https://www.ncbi.nlm.nih.gov/pubmed/33353284
http://dx.doi.org/10.3324/haematol.2020.260331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719086/
https://www.ncbi.nlm.nih.gov/pubmed/33353284
http://dx.doi.org/10.3324/haematol.2020.260331

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