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ACE2 can act as the secondary receptor in the FcγR-dependent ADE of SARS-CoV-2 infection

It is unknown whether antibody-mediated enhancement (ADE) contributes to the pathogenesis of COVID-19, and the conditions for ADE needs to be elucidated. We demonstrated that without inducing an ACE2-independent ADE on Raji cells, the neutralizing antibody CB6, a mouse anti-S1 serum and convalescent...

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Detalles Bibliográficos
Autores principales: Wang, Zai, Deng, Tingting, Zhang, Yulian, Niu, Wenquan, Nie, Qiangqiang, Yang, Shengnan, Liu, Peipei, Pei, Pengfei, Chen, Long, Li, Haibo, Cao, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719361/
https://www.ncbi.nlm.nih.gov/pubmed/35005526
http://dx.doi.org/10.1016/j.isci.2021.103720