A spatio-temporal model to reveal oscillator phenotypes in molecular clocks: Parameter estimation elucidates circadian gene transcription dynamics in single-cells

We propose a stochastic distributed delay model together with a Markov random field prior and a measurement model for bioluminescence-reporting to analyse spatio-temporal gene expression in intact networks of cells. The model describes the oscillating time evolution of molecular mRNA counts through...

Descripción completa

Detalles Bibliográficos
Autores principales: Unosson, Måns, Brancaccio, Marco, Hastings, Michael, Johansen, Adam M., Finkenstädt, Bärbel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719734/
https://www.ncbi.nlm.nih.gov/pubmed/34919546
http://dx.doi.org/10.1371/journal.pcbi.1009698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719734/
https://www.ncbi.nlm.nih.gov/pubmed/34919546
http://dx.doi.org/10.1371/journal.pcbi.1009698

Ejemplares similares