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Biotechnological production optimization of argyrins – a potent immunomodulatory natural product class

Argyrins represent a family of cyclic octapeptides exhibiting promising immunomodulatory activity via inhibiting mitochondrial protein synthesis, which leads to reduced IL‐17 production by the T‐helper 17 cells. Argyrins are formed by a non‐ribosomal peptide synthetase (NRPS), originating from the m...

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Detalles Bibliográficos
Autores principales: Pogorevc, Domen, Müller, Rolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8719831/
https://www.ncbi.nlm.nih.gov/pubmed/34724343
http://dx.doi.org/10.1111/1751-7915.13959