Cargando…

Microglia Polarization from M1 toward M2 Phenotype Is Promoted by Astragalus Polysaccharides Mediated through Inhibition of miR-155 in Experimental Autoimmune Encephalomyelitis

Activated microglia is considered to be major mediators of the neuroinflammatory environment in demyelinating diseases of the central nervous system (CNS). Activated microglia are mainly polarized into M1 type, which plays a role in promoting inflammation and demyelinating. However, the proportion o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Xiaojun, Ma, Jinyun, Ding, Guiqing, Gong, Qianyi, Wang, Yuanhua, Yu, Hua, Cheng, Xiaodong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720009/ https://www.ncbi.nlm.nih.gov/pubmed/34976303 http://dx.doi.org/10.1155/2021/5753452

Ejemplares similares

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice
por: Ding, Guiqing, et al.
Publicado: (2021)

Bu Shen Yi Sui Capsule Alleviates Neuroinflammation and Demyelination by Promoting Microglia toward M2 Polarization, Which Correlates with Changes in miR-124 and miR-155 in Experimental Autoimmune Encephalomyelitis
por: Zha, Zheng, et al.
Publicado: (2021)

Astragalus Polysaccharide RAP Induces Macrophage Phenotype Polarization to M1 via the Notch Signaling Pathway
por: Wei, Wei, et al.
Publicado: (2019)

Protoporphyrin Treatment Modulates Susceptibility to Experimental Autoimmune Encephalomyelitis in miR-155-Deficient Mice
por: Zhang, Jinyu, et al.
Publicado: (2015)

Modulatory Effects of Astragalus Polysaccharides on T-Cell Polarization in Mice with Polymicrobial Sepsis
por: Hou, Yu-Chen, et al.
Publicado: (2015)

Apigenin Alleviates Autoimmune Uveitis by Inhibiting Microglia M1 Pro-Inflammatory Polarization
por: Shu, Nan, et al.
Publicado: (2023)

Clozapine Regulates Microglia and Is Effective in Chronic Experimental Autoimmune Encephalomyelitis
por: Ceylan, Ulaş, et al.
Publicado: (2021)

IL-17 Exerts Anti-Apoptotic Effect via miR-155-5p Downregulation in Experimental Autoimmune Encephalomyelitis
por: Ksiazek-Winiarek, Dominika, et al.
Publicado: (2017)

Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
por: Guo, Shenrui, et al.
Publicado: (2022)

Microglia and meningeal macrophages depletion delays the onset of experimental autoimmune encephalomyelitis
por: Montilla, Alejandro, et al.
Publicado: (2023)

Astragalus Polysaccharides Promote Wound Healing in Diabetic Rats by Upregulating PETN and Inhibiting the mTOR Pathway
por: Ma, Le
Publicado: (2022)

Protective effect of miR-33-5p on the M1/M2 polarization of microglia and the underlying mechanism
por: Chai, Song, et al.
Publicado: (2022)

Minocycline selectively inhibits M1 polarization of microglia
por: Kobayashi, K, et al.
Publicado: (2013)

Nogo receptor expression in microglia/macrophages during experimental autoimmune encephalomyelitis progression
por: Alrehaili, Amani A., et al.
Publicado: (2018)

Interferon-gamma ameliorates experimental autoimmune encephalomyelitis by inducing homeostatic adaptation of microglia
por: Tichauer, Juan E., et al.
Publicado: (2023)

MicroRNA-155 Implication in M1 Polarization and the Impact in Inflammatory Diseases
por: Pasca, Sergiu, et al.
Publicado: (2020)

Molecular Weight and Monosaccharide Composition of Astragalus Polysaccharides
por: Xu, Du-Juan, et al.
Publicado: (2008)

A Review of the Pharmacological Action of Astragalus Polysaccharide
por: Zheng, Yijun, et al.
Publicado: (2020)

Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer
por: Bamodu, Oluwaseun Adebayo, et al.
Publicado: (2019)

miR-155-5p regulates macrophage M1 polarization and apoptosis in the synovial fluid of patients with knee osteoarthritis
por: Li, Gui-Shi, et al.
Publicado: (2021)

Implications the Role of miR-155 in the Pathogenesis of Autoimmune Diseases
por: Pashangzadeh, Salar, et al.
Publicado: (2021)

Sex-Specific Effects of Microglia-Like Cell Engraftment during Experimental Autoimmune Encephalomyelitis
por: Han, Jinming, et al.
Publicado: (2020)

M1 Microglia-derived Exosomes Promote Activation of Resting Microglia and Amplifies Proangiogenic Effects through Irf1/miR-155-5p/Socs1 Axis in the Retina
por: Chen, Xi, et al.
Publicado: (2023)

Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation
por: Li, Zhi-Peng, et al.
Publicado: (2018)

Effects of Apigenin and Astragalus Polysaccharide on the Cryopreservation of Bull Semen
por: Wang, Hongtao, et al.
Publicado: (2021)

MiR-367 alleviates inflammatory injury of microglia by promoting M2 polarization via targeting CEBPA
por: Pei, Hui, et al.
Publicado: (2020)

Targeting the Shift from M1 to M2 Macrophages in Experimental Autoimmune Encephalomyelitis Mice Treated with Fasudil
por: Liu, Chunyun, et al.
Publicado: (2013)

Functional Expression of Choline Transporters in Microglia and Their Regulation of Microglial M1/M2 Polarization
por: Okada, Toshio, et al.
Publicado: (2022)

Shenlian extract attenuates myocardial ischaemia-reperfusion injury via inhibiting M1 macrophage polarization by silencing miR-155
por: Song, Min, et al.
Publicado: (2022)

Silencing miR-150 Ameliorates Experimental Autoimmune Encephalomyelitis
por: Hu, Zhaolan, et al.
Publicado: (2018)

Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
por: Xian, Xian, et al.
Publicado: (2022)

miR-99a regulates CD4(+) T cell differentiation and attenuates experimental autoimmune encephalomyelitis by mTOR-mediated glycolysis
por: Gu, Yuting, et al.
Publicado: (2021)

The mTOR kinase inhibitors polarize glioma-activated microglia to express a M1 phenotype
por: Lisi, Lucia, et al.
Publicado: (2014)

Optimization and evaluation of astragalus polysaccharide injectable thermoresponsive in-situ gels
por: Yu, Zugong, et al.
Publicado: (2017)

Wound healing effect of an Astragalus membranaceus polysaccharide and its mechanism
por: Zhao, Bingjiang, et al.
Publicado: (2017)

Effects of Astragalus Polysaccharides Nanoparticles on Cerebral Thrombosis in SD Rats
por: Sun, Qian, et al.
Publicado: (2020)

Synergist for antitumor therapy: Astragalus polysaccharides acting on immune microenvironment
por: Xu, Qian, et al.
Publicado: (2023)

Immunomodulatory activity of polysaccharides isolated from Clerodendrum splendens: Beneficial effects in experimental autoimmune encephalomyelitis
por: Kouakou, Koffi, et al.
Publicado: (2013)

miR-155 mediates inflammatory injury of hippocampal neuronal cells via the activation of microglia
por: Sun, Xiao-Hua, et al.
Publicado: (2019)

Seabuckthorn polysaccharide combined with astragalus polysaccharide ameliorate alcoholic fatty liver by regulating intestinal flora
por: Liu, Jiayue, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_k14otrnm0rk9qrkfpruk58mcl5