Transient expression of inactive RB in mesenchymal stem cells impairs their adipogenic potential and is associated with hypermethylation of the PPARγ2 promoter

The retinoblastoma gene product (pRb) is a chromatin-associated protein that can either suppress or promote activity of key regulators of tissue-specific differentiation. We found that twelve weeks after transfection of the exogenous active (ΔB/X and Δр34) or inactive (ΔS/N) forms of RB into the 10T...

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Detalles Bibliográficos
Autores principales: Baryshev, Mikhail, Petrov, Nikolai, Ryabov, Vladimir, Popov, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chongqing Medical University 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720652/
https://www.ncbi.nlm.nih.gov/pubmed/35005116
http://dx.doi.org/10.1016/j.gendis.2020.11.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720652/
https://www.ncbi.nlm.nih.gov/pubmed/35005116
http://dx.doi.org/10.1016/j.gendis.2020.11.001

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