Intranasal delivery of Clozapine using nanoemulsion-based in-situ gels: An approach for bioavailability enhancement

Limited solubility and hepatic first-pass metabolism are the main causes of low bioavailability of anti-schizophrenic drug, Clozapine (CZP). The objective of the study was to develop and validate nanoemulsion (NE) based in-situ gel of CZP for intranasal administration as an approach for bioavailabil...

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Detalles Bibliográficos
Autores principales: Abdulla, Nourhan A., Balata, Gehan F., El-ghamry, Hanaa A., Gomaa, Eman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720818/
https://www.ncbi.nlm.nih.gov/pubmed/35002385
http://dx.doi.org/10.1016/j.jsps.2021.11.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8720818/
https://www.ncbi.nlm.nih.gov/pubmed/35002385
http://dx.doi.org/10.1016/j.jsps.2021.11.006

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