Cargando…

Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway

Acute lung injury (ALI) is a severe disease that presents serious damage and excessive inflammation in lungs with high mortality without effective pharmacological therapy. Fluorofenidone (AKFPD) is a novel pyridone agent that has anti-fibrosis, anti-inflammation, and other pharmacological activities...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lv, Xin, Yao, Tingting, He, Rongling, He, Yijun, Li, Mengyu, Han, Yuanyuan, Zhang, Yan, Long, Lingzhi, Jiang, Guoliang, Cheng, Xiaoyun, Xie, Yanyun, Huang, Ling, Peng, Zhangzhe, Hu, Gaoyun, Li, Qianbin, Tao, Lijian, Meng, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721041/ https://www.ncbi.nlm.nih.gov/pubmed/34987397 http://dx.doi.org/10.3389/fphar.2021.772031

Ejemplares similares

Fluorofenidone Alleviates Renal Fibrosis by Inhibiting Necroptosis Through RIPK3/MLKL Pathway
por: Dai, Qin, et al.
Publicado: (2020)

Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice
por: Han, Yuanyuan, et al.
Publicado: (2021)

Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage
por: Liao, Xiaohua, et al.
Publicado: (2022)

Fluorofenidone affects hepatic stellate cell activation in hepatic fibrosis by targeting the TGF-β1/Smad and MAPK signaling pathways
por: Peng, Yu, et al.
Publicado: (2019)

Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP3 inflammasome and IL‐1β/IL‐1R1/MyD88/NF‐κB pathway
por: Song, Cheng, et al.
Publicado: (2016)

Protective effects of mefunidone on ischemia-reperfusion injury/Folic acid-induced acute kidney injury
por: Li, Jiajia, et al.
Publicado: (2022)

Corrigendum: Protective effects of Mefunidone on ischemia-reperfusion injury/folic acid-induced acute kidney injury
por: Li, Jiajia, et al.
Publicado: (2023)

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway
por: Yao, Minjun, et al.
Publicado: (2022)

Fluorofenidone Offers Improved Renoprotection at Early Interventions during the Course of Diabetic Nephropathy in db/db Mice via Multiple Pathways
por: Xiong, Xuan, et al.
Publicado: (2014)

Tamarixinin A Alleviates Joint Destruction of Rheumatoid Arthritis by Blockade of MAPK and NF-κB Activation
por: Zhuang, Yuanyuan, et al.
Publicado: (2017)

Homozygous mutation in DNAAF4 causes primary ciliary dyskinesia in a Chinese family
por: Jiang, Guoliang, et al.
Publicado: (2022)

Fluorofenidone Inhibits the Proliferation of Lung Adenocarcinoma Cells
por: Deng, Zheng-hao, et al.
Publicado: (2017)

Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways
por: Gao, Yao-Xin, et al.
Publicado: (2018)

Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage
por: Zeng, Jianhua, et al.
Publicado: (2023)

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect
por: Lu, Rui, et al.
Publicado: (2021)

Protective Effects of Punicalagin on Osteoporosis by Inhibiting Osteoclastogenesis and Inflammation via the NF-κB and MAPK Pathways
por: Wang, Wei, et al.
Publicado: (2020)

Chrysin Protects Against Titanium Particle-Induced Osteolysis by Attenuating Osteoclast Formation and Function by Inhibiting NF-κB and MAPK Signaling
por: Wu, Zuoxing, et al.
Publicado: (2022)

Tussilagone Inhibits Osteoclastogenesis and Periprosthetic Osteolysis by Suppressing the NF-κB and P38 MAPK Signaling Pathways
por: Hu, Xuantao, et al.
Publicado: (2020)

Anhuienoside C Ameliorates Collagen-Induced Arthritis through Inhibition of MAPK and NF-κB Signaling Pathways
por: Liu, Qing, et al.
Publicado: (2017)

N-Acetyldopamine Dimer Attenuates DSS-Induced Ulcerative Colitis by Suppressing NF-κB and MAPK Pathways
por: Huang, Li-Jun, et al.
Publicado: (2022)

Deacylcynaropicrin Inhibits RANKL-Induced Osteoclastogenesis by Inhibiting NF-κB and MAPK and Promoting M2 Polarization of Macrophages
por: Li, Zhikun, et al.
Publicado: (2019)

Bicyclol Attenuates Liver Inflammation Induced by Infection of Hepatitis C Virus via Repressing ROS-Mediated Activation of MAPK/NF-κB Signaling Pathway
por: Li, Hu, et al.
Publicado: (2018)

Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss
por: Xu, Shenggui, et al.
Publicado: (2021)

Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity
por: Deng, Wei, et al.
Publicado: (2022)

Magnoflorine Ameliorates Lipopolysaccharide-Induced Acute Lung Injury via Suppressing NF-κB and MAPK Activation
por: Guo, Shuai, et al.
Publicado: (2018)

Recombinant Human Endostatin Suppresses Mouse Osteoclast Formation by Inhibiting the NF-κB and MAPKs Signaling Pathways
por: Chen, Nong, et al.
Publicado: (2016)

Sesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-κB and MAPK Signaling Pathways
por: Yang, Xue, et al.
Publicado: (2021)

Schizandrin C regulates lipid metabolism and inflammation in liver fibrosis by NF-κB and p38/ERK MAPK signaling pathways
por: Chen, Panpan, et al.
Publicado: (2023)

Astragaloside IV Relieves Atherosclerosis and Hepatic Steatosis via MAPK/NF-κB Signaling Pathway in LDLR(−/−) Mice
por: Zhang, Yifan, et al.
Publicado: (2022)

Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways
por: Zhi, Xin, et al.
Publicado: (2020)

Bergenin Monohydrate Attenuates Inflammatory Response via MAPK and NF-κB Pathways Against Klebsiella pneumonia Infection
por: Tang, Qihe, et al.
Publicado: (2021)

Atractylenolide I Ameliorates Acetaminophen-Induced Acute Liver Injury via the TLR4/MAPKs/NF-κB Signaling Pathways
por: Du, Zhongyan, et al.
Publicado: (2022)

Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis
por: Yang, Hui, et al.
Publicado: (2019)

Design, Synthesis and Anti-fibrosis Activity Study of N(1)-Substituted Phenylhydroquinolinone Derivatives
por: Wu, Ling, et al.
Publicado: (2012)

Combination Effect of Three Main Constituents From Sarcandra glabra Inhibits Oxidative Stress in the Mice Following Acute Lung Injury: A Role of MAPK-NF-κB Pathway
por: Liu, Chun-Ping, et al.
Publicado: (2021)

Allyl methyl trisulfide protected against LPS-induced acute lung injury in mice via inhibition of the NF-κB and MAPK pathways
por: Wang, Shuo, et al.
Publicado: (2022)

Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling
por: Chen, Zhiqian, et al.
Publicado: (2021)

Eupatilin attenuates the senescence of nucleus pulposus cells and mitigates intervertebral disc degeneration via inhibition of the MAPK/NF-κB signaling pathway
por: Yang, Huan, et al.
Publicado: (2022)

Curcumin Alleviates oxLDL Induced MMP-9 and EMMPRIN Expression through the Inhibition of NF-κB and MAPK Pathways in Macrophages
por: Cao, Jiatian, et al.
Publicado: (2017)

Chondro-Protective Effects of Shikimic Acid on Osteoarthritis via Restoring Impaired Autophagy and Suppressing the MAPK/NF-κB Signaling Pathway
por: You, Hongbo, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_psc6ev2etk9vhjsatfj8gh2a7g