Mitapivat, a novel pyruvate kinase activator, for the treatment of hereditary hemolytic anemias

Mitapivat (AG-348) is a novel, first-in-class oral small molecule allosteric activator of the pyruvate kinase enzyme. Mitapivat has been shown to significantly upregulate both wild-type and numerous mutant forms of erythrocyte pyruvate kinase (PKR), increasing adenosine triphosphate (ATP) production...

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Detalles Bibliográficos
Autores principales: Al-Samkari, Hanny, van Beers, Eduard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721383/
https://www.ncbi.nlm.nih.gov/pubmed/34987744
http://dx.doi.org/10.1177/20406207211066070

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721383/
https://www.ncbi.nlm.nih.gov/pubmed/34987744
http://dx.doi.org/10.1177/20406207211066070

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