Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction

Following traumatic brain injury (TBI), raised cerebral lactate/pyruvate ratio (LPR) reflects impaired energy metabolism. Raised LPR correlates with poor outcome and mortality following TBI. We prospectively recruited patients with TBI requiring neurocritical care and multimodal monitoring, and util...

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Detalles Bibliográficos
Autores principales: Khellaf, Abdelhakim, Garcia, Nuria Marco, Tajsic, Tamara, Alam, Aftab, Stovell, Matthew G, Killen, Monica J, Howe, Duncan J, Guilfoyle, Mathew R, Jalloh, Ibrahim, Timofeev, Ivan, Murphy, Michael P, Carpenter, T Adrian, Menon, David K, Ercole, Ari, Hutchinson, Peter J, Carpenter, Keri LH, Thelin, Eric P, Helmy, Adel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721534/
https://www.ncbi.nlm.nih.gov/pubmed/34494481
http://dx.doi.org/10.1177/0271678X211042112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721534/
https://www.ncbi.nlm.nih.gov/pubmed/34494481
http://dx.doi.org/10.1177/0271678X211042112

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