Serine catabolism generates liver NADPH and supports hepatic lipogenesis

Carbohydrate can be converted into fat by de novo lipogenesis, a process upregulated in fatty liver disease. Chemically, de novo lipogenesis involves polymerization and reduction of acetyl-CoA, using NADPH as the electron donor. The feedstocks used to generate acetyl-CoA and NADPH in lipogenic tissu...

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Detalles Bibliográficos
Autores principales: Zhang, Zhaoyue, TeSlaa, Tara, Xu, Xincheng, Zeng, Xianfeng, Yang, Lifeng, Xing, Gang, Tesz, Gregory J, Clasquin, Michelle F, Rabinowitz, Joshua D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721747/
https://www.ncbi.nlm.nih.gov/pubmed/34845393
http://dx.doi.org/10.1038/s42255-021-00487-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721747/
https://www.ncbi.nlm.nih.gov/pubmed/34845393
http://dx.doi.org/10.1038/s42255-021-00487-4

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