Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer’s disease

Soluble amyloid precursor protein-alpha (sAPPα) is a regulator of neuronal and memory mechanisms, while also having neurogenic and neuroprotective effects in the brain. As adult hippocampal neurogenesis is impaired in Alzheimer’s disease, we tested the hypothesis that sAPPα delivery would rescue adu...

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Detalles Bibliográficos
Autores principales: Ohline, Shane M., Chan, Connie, Schoderboeck, Lucia, Wicky, Hollie E., Tate, Warren P., Hughes, Stephanie M., Abraham, Wickliffe C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721980/
https://www.ncbi.nlm.nih.gov/pubmed/34980189
http://dx.doi.org/10.1186/s13041-021-00889-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8721980/
https://www.ncbi.nlm.nih.gov/pubmed/34980189
http://dx.doi.org/10.1186/s13041-021-00889-1

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