Prevotellaceae produces butyrate to alleviate PD-1/PD-L1 inhibitor-related cardiotoxicity via PPARα-CYP4X1 axis in colonic macrophages

BACKGROUND: Immune checkpoint inhibitor-related cardiotoxicity is one of the most lethal adverse effects, and thus, the identification of underlying mechanisms for developing strategies to overcome it has clinical importance. This study aimed to investigate whether microbiota-host interactions contr...

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Detalles Bibliográficos
Autores principales: Chen, Yaxin, Liu, Yanzhuo, Wang, Yang, Chen, Xuewei, Wang, Chenlong, Chen, Xuehan, Yuan, Xi, Liu, Lilong, Yang, Jing, Zhou, Xiaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722009/
https://www.ncbi.nlm.nih.gov/pubmed/34980222
http://dx.doi.org/10.1186/s13046-021-02201-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722009/
https://www.ncbi.nlm.nih.gov/pubmed/34980222
http://dx.doi.org/10.1186/s13046-021-02201-4

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